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Methotrexate EP Impurity B

Catalog No. : DI-M-42743
CAS Number : 54-62-6
Molecular Weight : 440.42
Molecular Formula : C19H20N8O5
Synonym : 2-(4-((2,4-Diaminopteridin-6-yl)methylamino)-benzamido)pentanedopteroylglutroylglutamic acid;Aminopterin.
Application Notes : Aminopterin, a 4-amino analog of folic acid, is an antineoplastic drug with immunosuppressive properties used in chemotherapy. Aminopterin is a synthetic derivative of pterin. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis. This results in the depletion of nucleotide precursors and inhibition of DNA, RNA, and protein synthesis.;Impurity in commercial preparations of Aminopterin
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