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trans-Abacavir Dihydrochloride




Catalog No. : DI-BI-00051
CAS Number : 267668-71-3
Molecular Weight : 359.25
Molecular Formula : C14H20Cl2N6O
Synonym : [(1R,4R)‐4‐[2‐amino‐6‐(cyclopropylamino)‐9H‐purin‐9‐yl]cyclopent‐2‐en‐1‐yl]methanol hydrochloride
Application Notes : trans-Abacavir Dihydrochloride is an impurity of Abacavir. Abacavir is a carbocyclic 2?-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
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