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1,3-Bis(2-chloroethyl)urea




Catalog No. : DI-T-06836
CAS Number : 2214-72-4
Molecular Weight : 185.05
Molecular Formula : C5H10Cl2N2O
Synonym :
Application Notes : 1,3-Bis(2-chloroethyl)urea is an impurity in the synthesis of Carmustine , an alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death.;Impurity in commercial preparations of Carmustine
References :Stahl, et al.: Chem. Res. Toxicol., 5, 106 (1992), Kokkinakis, D.M., et al.: Clin. Cancer Res., 5(11), 3676 (1999), Hickman, M.J., et al.: Proc. Natl. Acad. Sci. USA, 96(19), 10764 (1999),